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122 Wolf HallNewark, DE 19716<div class="ExternalClass49340C882AFF43A2A538691A2F961E21"><p> I primarily examine the effects of developmental alcohol exposure on the brain throughout development and adulthood. I use a model of third-trimester alcohol exposure to look at how alcohol specifically damages some brain regions while others show resilience. Using neuroanatomical tract tracing, immunofluorescence, and confocal microscopy, my PhD research looks into the mechanism by which alcohol exposure during development changes the prefrontal cortex (responsible for complex behaviors and planning) and hippocampus (responsible for memory), and that some of these changes might be caused by loss of neurons in the thalamus (that coordinates activity between the previous two structures). </p><p>     By combining my anatomical findings with behavioral testing, we can see how damage to the 3 brain regions that I mentioned above relate to difficulties that individuals diagnosed with Fetal Alcohol Spectrum Disorders often have with memory and other complex cognitive tasks. Using multivariate statistical analyses, we hope to identify whether alcohol impacts behavior through neuroanatomical changes that we observe within individuals. Understanding the relationship between alcohol, brain structures, and behavior will allow us to identify potential therapeutic targets for individuals with memory and cognitive difficulties.</p><p>     Our hope is that we can discover ways to enrich the connections between these three regions, regardless of the loss of neurons that typically occur following alcohol exposure, to improve memory and other cognitive functions. My research contributes to our understanding of the way the learning and memory regions of the brain connect to each other, and lends itself to looking at functional connectivity and therapeutic outcomes in future experiments. </p><br></div><div class="ExternalClassC417D5DBB76D4BB1955086ACD5F87D87"><p>PhD in Psychological & Brain Sciences, University of Delaware, August 2020 (expected)</p><p>MS in Neuroscience, University of Delaware, December 2018</p><p>BS in Psychology<em> cum laude</em>, Stony Brook University, May 2014</p><p>Minor in Music Theory, Stony Brook University, May 2014</p></div><div class="ExternalClass6372D1C9E4D24558B1B90868C58FC20D"><p>NSCI100: Psychological and Brain Sciences</p><p>NSCI320: Introduction to Neuroscience <br></p><p>PSYC325: Child Psychology </p><p>PSYC314: Brain and Behavior</p></div><div class="ExternalClass1B7D18ED4C1A48B7BC15E81E802E46FF"><p><a href="https://scholar.google.com/citations?user=y--8plcAAAAJ" target="_blank" data-saferedirecturl="https://www.google.com/url?q=https://scholar.google.com/citations?user%3Dy--8plcAAAAJ&source=gmail&ust=1590846390635000&usg=AFQjCNFK3GnMGqtG9g4cQWYM7VAx8zJNdw">Zachary Gursky's Google Scholar Page</a></p><p><a href="https://www.ncbi.nlm.nih.gov/myncbi/1hqm5txJgjnkv/bibliography/public/" target="_blank" data-saferedirecturl="https://www.google.com/url?q=https://www.ncbi.nlm.nih.gov/myncbi/1hqm5txJgjnkv/bibliography/public/&source=gmail&ust=1590846390635000&usg=AFQjCNFT04a7JL80_VjA8E0sXePCnYisdw">Zachary Gursky's NCBI Bibliography</a></p><p><strong>Gursky, Z.H.</strong>, Spillman, E.C., & Klintsova, A.Y. (2020). Single-day postnatal alcohol exposure induces apoptotic cell death and causes long-term neuron loss in rodent thalamic nucleus reuniens. <em>Neuroscience, 435</em>, 124-134. doi:10.1016/j.neuroscience.2020.03.046</p><p><strong>Gursky, Z.H.</strong>, Savage, L.M., & Klintsova, A.Y. (2019). Nucleus reuniens of the midline thalamus of a rat is specifically damaged after early postnatal alcohol exposure. <em>NeuroReport, 30</em>(10), 748-752. doi:10.1097/WNR.0000000000001270. <strong>Figure 1 featured on journal cover</strong>.</p><p><strong>Gursky, Z.H.</strong>, Klintsova, A.Y. (2017). Wheel running and environmental complexity as a therapeutic intervention in an animal model of FASD. <em>J. Vis. Exp.</em> (120), e54947, doi:10.3791/54947. </p><p><strong>Gursky, Z.H.</strong>, Klintsova, A.Y. (2017). Frontal lobe dysfunction after developmental alcohol exposure: Implications from animal models. In R.R. Watson and S. Zibadi (Eds.) <em>Addictive Substances and Neurological Disease</em> (pp. 139-147). Elsevier. doi:10.1016/B978-0-12-805373-7.00015-3</p></div><div class="ExternalClass23C1651D8EBC49D88206D4586493B618"><p><strong>Gursky, Z. H.</strong>, Klintsova, A. Y. (2019). <em>Nucleus reuniens of ventral midline thalamus is highly susceptible to permanent neuron loss in the rat model of binge drinking during third trimester</em>. Poster, European Society for Biomedical Research on Alcoholism, Lille, France.</p><p><strong>Gursky, Z. H.</strong>, Klintsova, A. Y. (2019). <em>Thalamic nucleus reuniens is highly sensitive to alcohol-induced neuron loss in third-trimester-equivalent period of rat.</em> Talk, Fetal Alcohol Spectrum Disorders Study Group, Minneapolis, MN, USA.</p><p><strong>Gursky, Z. H.</strong>, Klintsova, A. Y. (2019). <em>Environmental factors shaping brain plasticity throughout the lifespan</em>. Symposium organizer, chair, and discussant, Eastern Psychological Association, New York City, NY, USA.</p><p>Klintsova, A.Y., Johansson, J.R., <strong>Gursky, Z.H.</strong> (2018). <em>Early postnatal alcohol exposure increases microglial density in the rat cerebellum that can be offset by voluntary exercise in adolescence</em>. Poster, Society for Neuroscience, San Diego, CA, USA.</p><p><strong>Gursky, Z. H.</strong>, Klintsova, A. Y. (2018). <em>Early postnatal ethanol exposure affects midline thalamus and behaviors dependent on prefrontal-thalamo-hippocampal circuit in adult rat</em>. Poster (<strong>President’s Young Investigator Awardee</strong>), International Society for Biomedical Research on Alcoholism, Kyoto, Japan.</p><p><strong>Gursky, Z.H.</strong>, Klintsova, A.Y. (2018). <em>Changes in the adult rat brain caused by developmental alcohol exposure: how animal models can support human treatments and diagnoses</em>. Talk, UD Graduate Students’ Forum, Newark, DE, USA.</p></div>DegreesCourses taught as TAPublications and PresentationsSelected Presentationszgursky@udel.eduGursky, Zachary302-831-2647<img alt="" src="/Images%20Bios/GurskyZachary2.JPG" style="BORDER:0px solid;" />Graduate StudentFacutly Advisor: Dr. Anna KlintsovaBackground and Interests

 

 

Programmed Cell Death in Neonatal Brain after Exposure to EthanolKlintsova, Anna;Gursky, Zacharyklintsov;zgursky<img alt="" src="/content-sub-site/PublishingImages/0323-klintsova2.JPG" width="223" style="BORDER:0px solid;" />
Prefrontal Cortex Plasticity and Therapeutic Interventions in Animal Model of FASDKlintsova, Anna;Gursky, Zacharyklintsov;zgursky<img alt="" src="/content-sub-site/PublishingImages/0323-klintsova3.JPG" width="279" style="BORDER:0px solid;" />

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