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Tania Roth
Associate Professor
Director of Graduate Education
Accepting graduate students for 2019-2020
Office Hours:
By Appointment Only
University of Delaware
Newark, DE 19716

Background and Interests

Dr. Roth received her Bachelor of Science degree in Biology from Roanoke College in 1998. She then completed her doctoral degree in 2004 in the laboratory of Dr. Regina Sullivan at the University of Oklahoma, where she investigated the neurobehavioral basis of infant-caregiver attachment and the ontogeny of fear learning and memory. She then did her postdoctoral research at the University of Alabama at Birmingham in the laboratory of David Sweatt, working on DNA methylation in CNS plasticity and behavior. In 2010 she joined the University of Delaware as an Assistant Professor of Psychological and Brain Sciences. Dr. Roth has received numerous honors and awards for scholarship, including a Young Investigator Award from the Brain & Behavior Research Foundation, the 2010 Ziskind-Somerfeld award from the Society of Biological Psychiatry, a 2015 Early Career Impact Award from the Federation of Associations in Behavioral & Brain Sciences, and she was elected a Kavli Fellow of the National Academy of Sciences in 2012. She is currently funded by the NIH, and her primary research interests are centered on identifying epigenetic changes associated with early-life caregiving experiences, particularly maltreatment. To better understand the relationship between caregiver maltreatment, epigenetic marking of the genome, and behavioral outcomes, her laboratory utilizes various molecular and behavior assays in developing and adult male and female rats. They focus on multiple brain regions that play a significant role in behavior and mental health, and that are particularly susceptible to the damaging effects of early-life stress.

Degrees

Ph.D., University of Oklahoma

Courses Regularly Taught

PSYC428: Nature vs. Nurture- Genetic and Environmental Determinants of Behavior

NSCI634: Stress and the Brain

NSCI637: Behavioral Epigenetics

Recent Publications

Dr. Tania Roth's Google Scholar Link

TS Doherty and TL Roth. 2016. Insight from animal models of environmentally-driven epigenetic changes in the developing and adult brain. In press, Development and Psychopathology.

KE Boschen, SE McKeown, TL Roth, and AY Klintsova. 2016. Impact of exercise and a complex environment on hippocampal dendritic morphology, Bdnf gene expression, and DNA methylation in male rat pups neonatally exposed to alcohol. In press, Developmental Neurobiology.

SM Keller and TL Roth. 2016. Environmental influences on the female epigenome and behavior. Environmental Epigenetics 2:1-10. 

​TS Doherty, A Forster, and TL Roth. 2016. Global and gene-specific DNA methylation alterations in the adolescent amygdala and hippocampus in an animal model of caregiver maltreatment. Behavioral Brain Research 298:55-61.

LW Ayers, A Asok, J Blaze, TL Roth, JB Rosen. 2016. Changes in dam and pup behavior following repeated postnatal exposure to a predator odor (TMT): A preliminary investigation in Long-Evans rats. Developmental Psychobiology 58:176-184. 

J Blaze and TL Roth. 2015. Evidence from clinical and animal model studies of the long-term and transgenerational impact of stress on DNA methylation. Seminars in Cell and Developmental Biology 43:76-84.​

J Blaze*, A Asok*, TL Roth. 2015. The long-term impact of adverse caregiving environments on epigenetic modifications and telomeres. Frontiers in Behavioral Neuroscience 9:79.

*designates equal author contribution

KE Boschen, KJ Criss, V Palamarchouk, TL Roth, AY Klintsova. 2015. Effects of developmental alcohol exposure vs. intubation stress on BDNF and TrkB expression in the hippocampus and frontal cortex of neonatal rats. International Journal of Developmental Neuroscience 43:16-24.

ED Roth, TL Roth, KM Money, S SenGupta, DE Eason, JD Sweatt. 2015. DNA methylation regulates neurophysiological spatial representation in memory formation. Neuroepigenetics 2:1-8.

PO McGowan and TL Roth. 2015. Epigenetic pathways through which experiences become linked with biology. Development and Psychopathology 27:637-648.

J Blaze, A Asok, and TL Roth. 2015. Long-term effects of early caregiving experiences on bdnf histone acetylation in the adult rat mPFC. Stress 18:607-615. 

Representative Publications

A Asok, K Bernard, JB Rosen, M Dozier, TL Roth. 2014. Infant-caregiver experiences alter telomere length in the brain. PLOS One 9:e101437.

J Blaze, L Scheuing, TL Roth. 2013. Differential methylation of genes in the medial prefrontal cortex of developing and adult rats following exposure to maltreatment or nurturing care during infancy. Developmental Neuroscience 35:306-316.

TL Roth, PR Zoladz, JD Sweatt, DM Diamond. 2011. Epigenetic modification of hippocampal BDNF DNA in adult rats in an animal model of post-traumatic stress disorder. Journal of Psychiatric Research 45:919-926.

TL Roth, FD Lubin, AJ Funk, and JD Sweatt. 2009. Lasting epigenetic influence of early-life adversity on the BDNF gene. Biological Psychiatry 65:760-769.

TL Roth and RM Sullivan. 2005. Memory of maltreatment: Neonatal behavioral and neural correlates of maternal maltreatment within the context of classical conditioning. Biological Psychiatry 57:823-831.

 

 

Aberrant DNA Methylation and Parenting Behavior associated with Caregiver MaltreatmentRoth, Tania;Doherty, Tiffany;Phillips, Natalia Ledo Husbytroth;tsd;nhusby<img alt="" src="/content-sub-site/PublishingImages/0323-roth2.JPG" width="222" style="BORDER:0px solid;" />
Epigenetic and behavioral outcomes associated with caregiver experiencesRoth, Tania;Doherty, Tiffany;Phillips, Natalia Ledo Husbytroth;tsd;nhusby<img alt="" src="/content-sub-site/PublishingImages/0323-roth5.JPG" width="315" style="BORDER:0px solid;" />
DNA methylation: Can early intervention affect DNA methylation?Dozier, Mary;Roth, Tania;Hoye, Julie;Doherty, Tiffanymdozier;troth;jhoye;tsd<img alt="" src="/content-sub-site/PublishingImages/Dozier%20lab.jpg" width="640" style="BORDER:0px solid;" />

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