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Examining the Etiology of Chronic Emotional & Behavioral Dysregulation in Adulthood. Examining the Etiology of Chronic Emotional & Behavioral Dysregulation in Adulthood. Sustained difficulties with emotion regulation, distress tolerance, and behavioral control are common across different forms of psychopathology, including externalizing traits, antisocial and borderline personality disorders, psychopathy, & PTSD. In addition to causing significant distress and functional impairment, these disorders have proven difficult to treat, partly due to a lack of understanding of the cognitive, affective, and environmental variables that maintain symptoms overtime. Research in the lab aims to gain a better understanding of the etiological mechanisms (cognition-emotion interactions, personality traits, biological vulnerabilities) that contribute to these disorders and their associated features (e.g., emotional lability, impulsivity, stress reactivity). The goal of this research is to gain a deeper understanding of the causes and developmental pathways to disorders characterized by chronic emotional and behavioral dysregulation.Samimi-Sadeh, Naominsadeh<img alt="" src="/Images%20Bios/9-1cftjo9.png" style="BORDER:0px solid;" />
Identifying Biomarkers of Disinhibition.Identifying Biomarkers of Disinhibition.Impulse control deficits and poor self-regulation are core features of a diverse array of harmful behaviors (aggression, substance use, risky sexual behavior) and mental disorders (antisocial personality disorder, PTSD, externalizing disorders) that increase risk for premature death and poor health outcomes. We are working on identifying neurobiological mechanisms that support adaptive inhibitory control in healthy populations and how these regulatory processes go awry in clinical samples. The goal of this work is to better understand the neural architecture of impulse control deficits across different forms of psychopathology and to clarify how the neural processes supporting inhibition interact with other cognitive, motivational, and emotional systems.Samimi-Sadeh, Naomi;Spielberg, Jeffreynsadeh;jspielberg<img alt="" src="/Images%20Bios/Picture1-1vpvuil.png" style="BORDER:0px solid;" />
Interaction of brain networks supporting motivation and inhibitionInteraction of brain networks supporting motivation and inhibitionAdaptive functioning depends on the rapid regulation of motivational processes, and disturbances in this regulation are key features of anxiety and depression. The CAD lab is conducting a number of studies aimed at understanding how brain networks supporting top-down inhibitory control interact with those involved in identifying the motivational importance of stimuli. This work is conducted in both healthy and anxious/depressed individuals, allowing us to describe both the typical manner in which these circuits interact and how divergence from the norm may lead to pathology.Spielberg, Jeffrey;Samimi-Sadeh, Naomijspielberg;nsadeh<img alt="" src="/content-sub-site/PublishingImages/proj_2.png" style="BORDER:0px solid;" />

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