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228 Wolf HallNewark, DE 19716<div class="ExternalClassDAF51DA93B5A4DE9A6EEC55658AC03B4"><p>Dr. Klintsova’s interest in brain plasticity has a long history, starting with her dissertation project on the effect of psychotropic and neuroleptic drugs on synaptic organization of the brain (EM study). After being awarded an International Brain Research Organization (IBRO) Fellowship in 1993, she continued her training in adult and developmental brain plasticity in the labs of Dr. Desmond, Dr. Brunjes (both – UVA) and later – in the lab of late Dr. William Greenough (UIUC). Working in these labs allowed her to obtain a broad training in behavioral neuroscience, quantitative neuroanatomy and developmental neuroplasticity. Her work demonstrated long-lasting impairments in several aspects of hippocampal, cerebellar and prefrontal cortical plasticity after neonatal exposure to alcohol: decreased adult neurogenesis in the hippocampus; reduced dendritic complexity and spine density in the medial prefrontal cortex (mPFC); and loss of neurons and synapses in the cerebellar cortex. Disruption of neuroplasticity by neonatal alcohol exposure may contribute to behavioral deficits seen in Fetal Alcohol Spectrum Disorders (FASD). The use of targeted therapeutic interventions allowed us to significantly increase brain plasticity and improve behavior in the model of alcohol exposure. Dr. Klintsova has published extensively on the subject of neuronal and synaptic plasticity as peer-reviewed empirical work and invited peer-reviewed reviews. She has written several peer-reviewed research papers regarding her long-standing interest in behavioral interventions that enhance neuroplasticity in normal and damaged brains​​.</p></div><div class="ExternalClass22B0B1C158BE491AA6DF807399ADBDF0"><p>Ph.D., Moscow State University</p></div><div class="ExternalClass488D3D107EA24C7FAA8442B314686717"><p>PSYC314: Brain and Behavior</p><p> NSCI320: Intro to Neuroscience</p><p> PSYC/NSCI467: Neuroplasticity Seminar</p><p> NSCI626: Advanced Neuroanatomy</p><p> NSCI629: Integrative Neuroscience</p></div><div class="ExternalClassE02719F7212544BE8403A03189D7C1C0"><p>​<a href="https://scholar.google.com/citations?user=PbwcoOAAAAAJ&hl=en&oi=ao">Dr. Klintsova's Google Scholar Link</a></p></div><div class="ExternalClass80516678D49640789F8FB4F51BAE8616"><p>​A.Y.Klintsova, W.T.Greenough. (1999)  Synaptic plasticity in cortical systems. <em>Current Opinions in Neurobiology,</em> v.9, p.203-208</p><p>Klintsova AY, Scamra C., Hoffman M., Goodlett CR., Napper RMA and WT. Greenough. (2002) Therapeutic effect of complex motor skill learning on binge-like postnatal alcohol-induced motor performance deficits: II. Quantitative Study of Synaptic Plasticity Using Unbiased Stereology. <em>Brain Research, 937,</em> p. 83-93.</p><p>Helfer JL, Calizo LH, Dong WK, Goodlett CR, Greenough WT, Klintsova AY (2009) Binge-like Postnatal Alcohol Exposure Triggers Cortical Gliogenesis in Adolescent Rats. <em>Journal of Comparative Neurology, 514</em>(3): 259-271.</p><p>Hamilton GF, Jablonski SA, Schuffino FL, St Cyr SA, Stanton ME, Klintsova AY (2014). Exercise and environment as an intervention for neonatal alcohol effects on hippocampal adult neurogenesis and learning. <em>Neuroscience, 265</em>; 274-290. PMID: 24513389</p><p>Boschen KE, Criss KJ, Palamarchouk V, Roth TL, Klintsova AY (2015) Effects of developmental alcohol exposure vs. intubation stress on BDNF and TrkB expression in the hippocampus and prefrontal cortex of neonatal rats. International Journal of Developmental Neuroscience, 43: 16-24. PMID: 25805052​</p></div><div class="ExternalClassC957FEB0E88B4C25A51A50A48484C8C2"><p>​<a href="http://www.mbfbioscience.com/blog/2017/01/microglia-fasd/">http://www.mbfbioscience.com/blog/2017/01/microglia-fasd/</a>​</p></div>DegreesCourses Regularly TaughtRecent PublicationsRepresentative PublicationsPress Coverage:klintsov@udel.edu/Documents%20Bios%20CVs/Klintsova-Anna-CV.pdfKlintsova, Anna302-831-0452<img alt="" src="/Images%20Bios/Klintsova.jpg" width="542" style="BORDER:0px solid;" />Professor Director, Behavioral Neuroscience Area and Graduate ProgramNot accepting graduate students for 2021-2022Office Hours:Wednesday 1:00 - 2:00122 Wolf Hall302-831-2647

 

 

BDNF expression following Behavioral Rehabilitation in a Rat Model of FASDKlintsova, Annaklintsov<img alt="" src="/content-sub-site/PublishingImages/0323-klintsova9.JPG" width="209" style="BORDER:0px solid;" />
Programmed Cell Death in Neonatal Brain after Exposure to EthanolKlintsova, Anna;Gursky, Zacharyklintsov;zgursky<img alt="" src="/content-sub-site/PublishingImages/0323-klintsova2.JPG" width="223" style="BORDER:0px solid;" />
Prefrontal Cortex Plasticity and Therapeutic Interventions in Animal Model of FASDKlintsova, Anna;Gursky, Zacharyklintsov;zgursky<img alt="" src="/content-sub-site/PublishingImages/0323-klintsova3.JPG" width="279" style="BORDER:0px solid;" />

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