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Jeff Rosen's lab studies the neurobiology of emotion, focusing on conditioned and unconditioned fear, and how research in animals can be translated to fear and anxiety disorder in humans. The research primarily uses Pavlovian fear conditioning and unconditioned, innate fear of predator odors to study the fundamental neural circuits involved in fear. This is approached from a neural systems perspective where neural circuits from sensory perception through motor output during emotional experiences are delineated at the neuroanatomical, cellular and molecular, and behavior levels of analysis. A major theme that has reoccurred over many studies is that the neural circuitry and pharmacology for learned fear is different from that for innate fear. In addition to its importance for basic understanding of brain systems during different types of fear, the research is performed with an eye towards translational significance for anxiety disorders in humans. Dr. Rosen's lab also teams up with a number of other labs to study fear conditioning in developing animals, the effects of early exposure to predator odors on expression of fear and anxiety in later life, and molecular correlates of early aversive and affiliative experiences in humans. The research has been funded throughout with grants from the National Science Foundation, National Institutes of Health, the Defense Department, and research foundations.
Ph.D., Wayne State University
PSYC414: Drugs and the Brain NSCI628: Advanced NeuropharmacologyNSCI630: Integrative Neuroscience II
Dr. Rosen's Google ScholarHeroux, N.A., Horgan, C.J., Pinizzotto, C.C., Rosen, J.B., and Stanton, M.E. (in press). Medial prefrontal and ventral hippocampal contributions to incidental context learning and memory in adolescent rats. Neurobiology of Learning and Memory.
Heroux, N. A., Horgan, C.J., Rosen, J. B., and Stanton, M. E. (2019). Cholinergic rescue of neurocognitive insult following third-trimester equivalent alcohol exposure in rats. Neurobiology of Learning and Memory.
An, Y. W., Lobacz, A. D., Lehmann, T., Baumeister, J., Rose, W. C., Higginson, J. S., Rosen, J., and Swanik, C.B. (in press). Negative Emotion Alters Joint Stiffness Regulation Strategies After Anterior Cruciate Ligament Injury. Journal of Athletic Training.
Heroux, N. A., Robinson-Drummer, P. A., Kawan, M., Rosen, J. B., & Stanton, M. E. (2019). Neonatal ethanol exposure impairs long-term context memory formation and prefrontal immediate early gene expression in adolescent rats. Behavioural Brain Research, 359, 386–395.
An, Y. W., Lobacz, A. D., Lehmann, T., Baumeister, J., Rose, W. C., Higginson, J. S., Rosen, J., and Swanik, C.B. (2019). Neuroplastic changes in anterior cruciate ligament reconstruction patients from neuromechanical decoupling. Scandinavian Journal of Medicine & Science in Sports, 29, 251-258.
Jablonski, S. A., Robinson-Drummer, P. A., Schreiber, W. B., Asok, A., Rosen, J. B., & Stanton, M. E. (2018). Impairment of the context preexposure facilitation effect in juvenile rats by neonatal alcohol exposure is associated with decreased Egr-1 mRNA expression in the prefrontal cortex. Behavioral Neuroscience, 132(6), 497–511.
Asok, A., Draper, A., Hoffman, A.F., Schulkin, Jay, Carl R. Lupica, C.R., and Rosen, J.B. (2018). Optogenetic silencing of a corticotropin-releasing factor pathway from the central amygdala to the bed nucleus of the stria terminalis disrupts sustained fear. Molecular Psychiatry, 23, 914-922.
Robinson-Drummer, P.A., Chakraborty, T., Heroux, N. A., Rosen, J. B., and Stanton, M. E. (2018). Age and experience dependent changes in Egr-1 expression during the ontogeny of the context preexposure facilitation effect (CPFE). Neurobiology of Learning and Memory, 150:1-12.
Heroux, N.A., Osborne, B.F., Miller, L.A., Kawan, M., Buban, K.N., Rosen, J.B., and Stanton, M.E. (2018). Differential expression of the immediate early genes c-Fos, Arc, Egr-1, and Npas4 during long-term memory formation in the context preexposure facilitation effect (CPFE). Neurobiology of Learning and Memory, 147:128-138.
Donley, M.P. and Rosen, J.B. (2017). Novelty and fear conditioning induced gene expression in high and low states of anxiety. Learning & Memory, 24: 449-461.
Heroux, N.A., Rosen, J.B., and Stanton, M.E. (2017). Differential involvement of the medial prefrontal cortex across variants of contextual fear conditioning. Learning & Memory, 24, 322-330.
Dekel, S., Ein-Dor, T., Rosen, J.B., and Bonanno, G.A. (2017). Differences in cortisol response to trauma activation in individuals with and without comorbid PTSD and depression. Frontiers in Psychology, 8:797. doi: 10.3389/fpsyg.2017.00797.
Schreiber, W.B., Asok, A., Jablonski, S.A., Rosen, J.B. and Stanton, M.E. (2014). Egr-1 mRNA expression patterns in the prefrontal cortex, hippocampus, and amygdala during variants of contextual fear conditioning in adolescent rats. Brain Research,1576, 63-72.
Asok, A., Bernard, K., Dozier, M., Rosen, J.B. and Roth, T.L. (2014). Infant-caregiver experiences alter telomere length in the brain. PLoS ONE, 9(7), e101437.
Asok, A., Schreiber, W.B., Jablonski, S.A., Rosen, J.B. and Stanton, M.E. (2013). Egr-1 Increases in the prefrontal cortex following training in the context preexposure facilitation effect (CPFE) paradigm. Neurobiology of Learning and Memory, 106, 145-153.
Ayers, L. W., Asok, A., Heyward, F. and Rosen, J. B. (2013). Freezing to the predator odor 2,4,5 dihydro 2,5 trimethylthiazoline (TMT) is disrupted by olfactory bulb removal but not trigeminal nerve deafferentation. Behavioural Brain Research, 253, 54-59.
Dekel, S., Ein-Dor, T., Gordon, M.K., Rosen, J.B. and Bonanno, G.A. (2013). Cortisol and PTSD Symptoms among Male and Female High-Exposure 9/11 Survivors. Journal of Traumatic Stress, 26, 261-265.
Asok, A., Bernard, K., Roth, T.L., Rosen, J.B. and Dozier, M. (2013). Parental Responsiveness moderates the association between early-life stress and reduced telomere length. Development and Psychopathology, 25, 577-585.
Asok, A., Ayers, L.W. Awoyemi, B., Schulkin, J. and Rosen, J.B. (2013). Immediate Early Gene and Neuropeptide Expression Following Exposure to the Predator Odor, 2,5-dihydro-2,4,5-trimethylthiazoline (TMT). Behavioural Brain Research, 248, 85-93.
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