| The Role of MS/DBB Cholinergic input to the Hippocampus in Extinction Memory and Contextual Fear Memory Generalization | The Role of MS/DBB Cholinergic input to the Hippocampus in Extinction Memory and Contextual Fear Memory Generalization | Current definitions of the extinction circuit in the mammalian brain focus on medial prefrontal cortical inhibition of amygdala activity and subcortical substrates. We have previously shown that cholinergic neurons in the medial septum and diagonal bands of Broca (MS/DBB) are critical for acquisition of extinction. However, neural circuitry through which these neurons modulate extinction memory processes are unknown. In this study, we test the hypothesis that MS/DBB cholinergic input to the dorsal hippocampus is critical for acquisition of extinction memory. Undergraduate Researchers: Jennifer Staib
| Knox, Dayan | dayank | | <img alt="" src="/content-sub-site/PublishingImages/Figure%203ii.jpg" width="640" style="BORDER:0px solid;" /> | | | | | |
| Nature of Extinction Retention Deficits in the Single Prolonged Stress Paradigm | Nature of Extinction Retention Deficits in the Single Prolonged Stress Paradigm | We have previously shown that exposing rats to single prolonged stress results in extinction retention deficits. However, it is not clear if this is due to enhanced fear memory or deficits in extinction memory. Our previous attempts to address this question using behavioral methods were inconclusive. In this study we used changes in expression of transcription factors as measures of neural activity to map neural activity throughout the fear circuit during fear memory formation and extinction memory formation. By doing this we will attempt to determine if single prolonged stress exposure leads to extinction retention deficits by altering neural activity during fear memory formation or extinction memory formation. Undergraduate Researchers: Jennifer Staib, Thomas DePietro
| Knox, Dayan | dayank | | <img alt="" src="/content-sub-site/PublishingImages/Graphical%20abstract.jpg" width="640" style="BORDER:0px solid;" /> | | | | | |
| The Role of Glucocorticoid Binding During Fear Conditioning in SPS-Induced Extinction Retention Deficits | The Role of Glucocorticoid Binding During Fear Conditioning in SPS-Induced Extinction Retention Deficits | We have previously shown that exposing rats to single prolonged stress results in extinction retention deficits and that inhibiting glucocorticoid release during fear conditioning exacerbates these deficits. These previous findings suggest that single prolonged stress-induced changes in glucocorticoid receptors can be adaptive. We will test this hypothesis by showing that activation of glucocorticoid receptors in the ventral hippocampus of single prolonged stressed rats during fear conditioning leads to attenuated extinction retention deficits in rats exposed to single prolonged stress. Undergraduate Researchers: Jennifer Staib, Caroline Lawless, Thomas DePietro
| Knox, Dayan | dayank | | <img alt="" src="/content-sub-site/PublishingImages/Metyrapone%20pilot%20data.jpg" width="640" style="BORDER:0px solid;" /> | | | | | |
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