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  • Dayan Knox, Assistant Professor

    Assistant Professor
    University of Delaware
    217 Wolf Hall
    Newark, DE 19716
    302-831-7577

    Biography

    Stress and Central Arousal Systems

    Peripheral hormones (e.g. glucocorticoids) and central ascending arousal systems (e.g. locus coeruleus efferents) contribute to cognitive/emotional processes that are critical for normal psychological functioning. These systems are also sensitive to stress, and under certain circumstances, may contribute to abnormal cognitive/emotional processes that result in psychiatric disorders. My research interests concern exploring how stress-induced changes in peripheral hormonal and ascending arousal systems contribute to abnormal cognitive/emotional processes.

    Degrees

    Ph.D.​, The Ohio State University​

    Courses Regularly Taught

    NSCI320 - Introduction to Neuroscience

    PSYC314 - Brain and Behavior

    Recent Publications

    Dr. Knox's NCBI Link

    Knox, D. and Keller, S.M. (2015). Cholinergic neuronal lesions in the medial septum and vertical limb of the Diagonal Bands of Broca induce contextual fear memory generalization and impair acquisition of fear extinction. Hippocampus (in press). ​

    Keller, S.M., Schreiber, W.B., Stanfield, B.R., Knox, D. (2015). Inhibiting corticosterone synthesis during fear memory formation exacerbates cued fear extinction memory deficits within the single prolonged stress model. Behavioural Brain Research 287: 182 - 186.

    Keller, S.M., Schreiber, W.B., Staib, J.S., Knox, D. (2015). Sex differences in the single prolonged stress model. Behavioural Brain Research 286: 29-32.

    George, S.A., Stout, S., Tan, M., Knox, D., Liberzon, I. (2013). Early handling attenuates enhancement of glucocorticoid receptors in the prefrontal cortex in an animal model of post-traumatic stress disorder. Biology of Mood and Anxiety Disorders 3(1): 22.

    Eagle, A., Knox, D., Roberts, M.M., Mulo, K., Liberzon, I., Galloway, M.P., and Perrine, S.A. (2013). Single prolonged stress enhances hippocampal glucocorticoid receptor and phosphorylated protein kinase B levels. Neuroscience Research 75, 130-137.

    George, S.A., Knox, D., Curtis, A., Aldridge, J.W., Valentino, R., and Liberzon, I. (2013). Altered noradrenergic activity in an animal model of PTSD. European Journal of Neuroscience 37, 901-909.

    Knox, D., Nault, T., Henderson, C., and Liberzon, I. (2012). Glucocorticoid Receptors And Extinction Retention Deficits In The Single Prolonged Stress Model. Neuroscience, 223: 163-173.

    Knox, D., Fitzpatrick, C.J., George, S.A., Abelson, J.A., and Liberzon, I. (2012). Unconditioned fear is enhanced in an appetitive context. Neurobiology of Learning and Memory: (97)4: 386 - 392.

    Knox, D., George, S.A., Fitzpatrick, C.J., Rabinak, C., Maren, S., and Liberzon, I. (2012). Single prolonged stress disrupts retention of extinguished fear in rats. Learning & Memory, 19(2): 43 - 49.

    Liberzon, I and Knox, D. (2012). Expanding Our Understanding Of Neurobiological Mechanisms Of Resilience By Using Animal Models. Neuropsychopharmacology, 37(2): 317 - 318.

    Fitzpatrick, C., Knox, D., and Liberzon, I. (2011). Inactivation of the prelimbic cortex enhances TMT-induced freezing. Behavioural Brain Research: 221(1): 320 – 323.

    Knox, D., Perrine, S, George, S., Galloway, M., and Liberzon, I. (2010). Single prolonged stress decreases glutamate, glutamine, and creatine concentrations in the rat medial prefrontal cortex. Neuroscience Letters, 480(1): 16 – 20.

    Knox, D. and Berntson, G. G. (2008). Cortical modulation by nucleus basalis magnocellularis corticopetal cholinergic neurons during anxiety-like states are reflected by decreases in delta. Brain Research 1227: 142 – 157.

    Knox, D., Holly B., Norman, J. G., and Berntson G. G., (2008). Nucleus basalis magnocellularis and substantia innominata corticopetal cholinergic lesions attenuate freezing induced by predator odor. Behavioral Neuroscience 122(3): 601-610.

    Knox, D., and Berntson, G. G., (2006). Effect of nucleus basalis magnocellularis cholinergic lesions on fear-like and anxiety-like behavior. Behavioral Neuroscience 120(2): 307-312.

    Lorzano, D.L., Norman, J. G., Knox, D., Wood, B. L., Miller, B. D., Emery, C. F., and Berntson, G. G. (2006). Where to B in dZ/dt. Psychophysiology 44(1): 113-119.

    Knox, D., Berntson, G. G., and Sarter, M. (2004). Visceral afferent bias on cortical processing: role of adrenergic afferents to the basal forebrain cholinergic system. Behavioral Neuroscience 118(6): 1455-1459.

    Berntson, G. G., Shafi, R., Knox, D. and Sarter, M. (2003). Blockade of epinephrine priming of the cerebral auditory evoked response by cortical cholinergic deafferentation. Neuroscience 116: 179-86.

    Representative Publications

    ​Knox, D., Nault, T., Henderson, C., and Liberzon, I. (2012). Glucocorticoid Receptors And Extinction Retention Deficits In The Single Prolonged Stress Model. Neuroscience, 223: 163-173.

    Knox, D., George, S.A., Fitzpatrick, C.J., Rabinak, C., Maren, S., and Liberzon, I. (2012). Single prolonged stress disrupts retention of extinguished fear in rats. Learning & Memory, 19(2): 43 - 49.
    Fitzpatrick, C., Knox, D., and Liberzon, I. (2011). Inactivation of the prelimbic cortex enhances TMT-induced freezing. Behavioural Brain Research: 221(1): 320 – 323.

    Knox, D. and Berntson, G. G. (2008). Cortical modulation by nucleus basalis magnocellularis corticopetal cholinergic neurons during anxiety-like states are reflected by decreases in delta. Brain Research 1227: 142 – 157.

    Knox, D., and Berntson, G. G., (2006). Effect of nucleus basalis magnocellularis cholinergic lesions on fear-like and anxiety-like behavior. Behavioral Neuroscience 120(2): 307-312.

 

 

217 Wolf HallNewark, DE 19716<div class="ExternalClass750CED126C704AAABAED1CBC01C20E51"><p>Stress and Central Arousal Systems</p><p> Peripheral hormones (e.g. glucocorticoids) and central ascending arousal systems (e.g. locus coeruleus efferents) contribute to cognitive/emotional processes that are critical for normal psychological functioning. These systems are also sensitive to stress, and under certain circumstances, may contribute to abnormal cognitive/emotional processes that result in psychiatric disorders. My research interests concern exploring how stress-induced changes in peripheral hormonal and ascending arousal systems contribute to abnormal cognitive/emotional processes.</p></div><div class="ExternalClassE4561ACBC9604C7186544DDF0690DBF0"><p>Ph.D.​, The Ohio State University​</p></div><div class="ExternalClassD7C8A68BB8B1403C9A7215F8DC27B103"><p>NSCI320 - Introduction to Neuroscience</p><p> PSYC314 - Brain and Behavior</p></div><div class="ExternalClassEAD760C8F38B4921A87EEABC45B643F1"><p>​<a href="http://www.ncbi.nlm.nih.gov/sites/myncbi/10ioclymaiaA3/bibliography/47206634/public/?sort=date&direction=ascending">Dr. Knox's NCBI Link</a></p><p>Knox, D. and Keller, S.M. (2015). Cholinergic neuronal lesions in the medial septum and vertical limb of the Diagonal Bands of Broca induce contextual fear memory generalization and impair acquisition of fear extinction. Hippocampus (in press). ​</p><p>Keller, S.M., Schreiber, W.B., Stanfield, B.R., Knox, D. (2015). Inhibiting corticosterone synthesis during fear memory formation exacerbates cued fear extinction memory deficits within the single prolonged stress model. <em>Behavioural Brain Research 287</em>: 182 - 186.</p><p>Keller, S.M., Schreiber, W.B., Staib, J.S., Knox, D. (2015). Sex differences in the single prolonged stress model. <em>Behavioural Brain Research 286</em>: 29-32.</p><p>George, S.A., Stout, S., Tan, M., Knox, D., Liberzon, I. (2013). Early handling attenuates enhancement of glucocorticoid receptors in the prefrontal cortex in an animal model of post-traumatic stress disorder. <em>Biology of Mood and Anxiety Disorders 3</em>(1): 22.</p><p>Eagle, A., Knox, D., Roberts, M.M., Mulo, K., Liberzon, I., Galloway, M.P., and Perrine, S.A. (2013). Single prolonged stress enhances hippocampal glucocorticoid receptor and phosphorylated protein kinase B levels. <em>Neuroscience Research 75</em>, 130-137.</p><p>George, S.A., Knox, D., Curtis, A., Aldridge, J.W., Valentino, R., and Liberzon, I. (2013). Altered noradrenergic activity in an animal model of PTSD. <em>European Journal of Neuroscience 37</em>, 901-909.</p><p>Knox, D., Nault, T., Henderson, C., and Liberzon, I. (2012). Glucocorticoid Receptors And Extinction Retention Deficits In The Single Prolonged Stress Model. <em>Neuroscience, 223</em>: 163-173.</p><p>Knox, D., Fitzpatrick, C.J., George, S.A., Abelson, J.A., and Liberzon, I. (2012). Unconditioned fear is enhanced in an appetitive context. <em>Neurobiology of Learning and Memory</em>: (97)4: 386 - 392.</p><p>Knox, D., George, S.A., Fitzpatrick, C.J., Rabinak, C., Maren, S., and Liberzon, I. (2012). Single prolonged stress disrupts retention of extinguished fear in rats. <em>Learning & Memory, 19</em>(2): 43 - 49.</p><p>Liberzon, I and Knox, D. (2012). Expanding Our Understanding Of Neurobiological Mechanisms Of Resilience By Using Animal Models. <em>Neuropsychopharmacology, 37</em>(2): 317 - 318.</p><p>Fitzpatrick, C., Knox, D., and Liberzon, I. (2011). Inactivation of the prelimbic cortex enhances TMT-induced freezing. <em>Behavioural Brain Research: 221</em>(1): 320 – 323.</p><p>Knox, D., Perrine, S, George, S., Galloway, M., and Liberzon, I. (2010). Single prolonged stress decreases glutamate, glutamine, and creatine concentrations in the rat medial prefrontal cortex. <em>Neuroscience Letters, 480</em>(1): 16 – 20.</p><p>Knox, D. and Berntson, G. G. (2008). Cortical modulation by nucleus basalis magnocellularis corticopetal cholinergic neurons during anxiety-like states are reflected by decreases in delta. <em>Brain Research 1227</em>: 142 – 157.</p><p>Knox, D., Holly B., Norman, J. G., and Berntson G. G., (2008). Nucleus basalis magnocellularis and substantia innominata corticopetal cholinergic lesions attenuate freezing induced by predator odor. <em>Behavioral Neuroscience 122</em>(3): 601-610.</p><p>Knox, D., and Berntson, G. G., (2006). Effect of nucleus basalis magnocellularis cholinergic lesions on fear-like and anxiety-like behavior. <em>Behavioral Neuroscience 120</em>(2): 307-312.</p><p>Lorzano, D.L., Norman, J. G., Knox, D., Wood, B. L., Miller, B. D., Emery, C. F., and Berntson, G. G. (2006). Where to B in dZ/dt. <em>Psychophysiology 44</em>(1): 113-119.</p><p>Knox, D., Berntson, G. G., and Sarter, M. (2004). Visceral afferent bias on cortical processing: role of adrenergic afferents to the basal forebrain cholinergic system. <em>Behavioral Neuroscience 118</em>(6): 1455-1459.</p><p>Berntson, G. G., Shafi, R., Knox, D. and Sarter, M. (2003). Blockade of epinephrine priming of the cerebral auditory evoked response by cortical cholinergic deafferentation. <em>Neuroscience 116</em>: 179-86.</p></div><div class="ExternalClass3C1772C433C64D9E8617C65C54E20DAB"><p>​Knox, D., Nault, T., Henderson, C., and Liberzon, I. (2012). Glucocorticoid Receptors And Extinction Retention Deficits In The Single Prolonged Stress Model. <em>Neuroscience, 223</em>: 163-173.<br></p><p>Knox, D., George, S.A., Fitzpatrick, C.J., Rabinak, C., Maren, S., and Liberzon, I. (2012). Single prolonged stress disrupts retention of extinguished fear in rats. Learning & Memory, 19(2): 43 - 49.<br>Fitzpatrick, C., Knox, D., and Liberzon, I. (2011). Inactivation of the prelimbic cortex enhances TMT-induced freezing. <em>Behavioural Brain Research: 221</em>(1): 320 – 323.<br></p><p>Knox, D. and Berntson, G. G. (2008). Cortical modulation by nucleus basalis magnocellularis corticopetal cholinergic neurons during anxiety-like states are reflected by decreases in delta.<em> Brain Research 1227</em>: 142 – 157.<br></p><p>Knox, D., and Berntson, G. G., (2006). Effect of nucleus basalis magnocellularis cholinergic lesions on fear-like and anxiety-like behavior. <em>Behavioral Neuroscience 120</em>(2): 307-312.</p></div>DegreesCourses Regularly TaughtRecent PublicationsRepresentative Publicationsdayank@UDel.Edu/Documents%20Bios%20CVs/Knox-Dayan-CV.pdfKnox, Dayan302-831-7577<img alt="" src="/Images%20Bios/Dayan%20Knox.JPG" style="BORDER:0px solid;" />Assistant ProfessorNot accepting graduate students for 2020-2021Office Hours:Tuesday & Thursday 12:30 - 1:30093 McKinly Lab302-831-7624http://knox.psych.udel.edu/

 

 

The Role of MS/DBB Cholinergic input to the Hippocampus in Extinction Memory and Contextual Fear Memory Generalization Knox, Dayandayank<img alt="" src="/content-sub-site/PublishingImages/Figure%203ii.jpg" width="640" style="BORDER:0px solid;" />
Nature of Extinction Retention Deficits in the Single Prolonged Stress ParadigmKnox, Dayandayank<img alt="" src="/content-sub-site/PublishingImages/Graphical%20abstract.jpg" width="640" style="BORDER:0px solid;" />
The Role of Glucocorticoid Binding During Fear Conditioning in SPS-Induced Extinction Retention DeficitsKnox, Dayandayank<img alt="" src="/content-sub-site/PublishingImages/Metyrapone%20pilot%20data.jpg" width="640" style="BORDER:0px solid;" />

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