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BDNF expression following Behavioral Rehabilitation in a Rat Model of FASDBDNF expression following Behavioral Rehabilitation in a Rat Model of FASDDevelopmental alcohol exposure causes serious physical, cognitive and behavioral deficits in children with Fetal Alcohol Spectrum Disorders (FASD) and occurs in up to 5% of live births per year. In this study we are seeking to examine mechanisms through which developmental alcohol exposure might impact the brain and behavior, as well as two interventions that have potential as behavioral therapies to ameliorate the damage caused by alcohol exposure. Klintsova, Annaklintsov<img alt="" src="/content-sub-site/PublishingImages/0323-klintsova9.JPG" width="209" style="BORDER:0px solid;" />
Programmed Cell Death in Neonatal Brain after Exposure to EthanolProgrammed Cell Death in Neonatal Brain after Exposure to EthanolExposure to alcohol in utero results in a dramatic increase of apoptosis (programmed cell death) in many areas of the brain, including hippocampus and cortical areas. To better understand the extent of the brain damage due to alcohol exposure we are analyzing the dynamics of apoptosis process and its internal regulation and compensation for the cell loss in the animal model of FASD. Klintsova, Anna;Gursky, Zacharyklintsov;zgursky<img alt="" src="/content-sub-site/PublishingImages/0323-klintsova2.JPG" width="223" style="BORDER:0px solid;" />
Prefrontal Cortex Plasticity and Therapeutic Interventions in Animal Model of FASDPrefrontal Cortex Plasticity and Therapeutic Interventions in Animal Model of FASDCortical areas of the brain are extremely plastic and capable of many changes due to exposure to drugs, teratogens, stress and environment. The work of my lab in the University of Delaware is demonstrating the extent of the dendritic and synaptic alterations in the prefrontal cortex of rats exposed to alcohol during the third trimester equivalent. Alcohol-related damage to developing prefrontal cortex has not been studied sufficiently, although cognitive impairments in executive functioning in human FASD suggest that the prefrontal cortex is damaged. Klintsova, Anna;Gursky, Zacharyklintsov;zgursky<img alt="" src="/content-sub-site/PublishingImages/0323-klintsova3.JPG" width="279" style="BORDER:0px solid;" />

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