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Jeffrey Spielberg

Assistant Professor
University of Delaware
212 Wolf Hall
Newark, DE 19716
302-831-7078
Lab Address: 405 Wolf Hall
Lab Phone: 302-831-4704

Biography

My program of research seeks to identify and understand the developmental mechanisms that lead to pathological anxiety and depression during adolescence, with a focus on the circuitry supporting the expression and regulation of emotion. We also examine potential biological factors that lead to the emergence of sex differences in such pathology during adolescence.  We are particularly interested in the contribution of pubertal factors (e.g., testosterone) and how related individual differences may place children at greater risk for pathology. The types of questions we ask include: What types of disturbances in brain circuitry predispose toward the development of anxiety? Are such brain networks organized differently, for instance less robust to disruption or less efficient in integrating information? Can we identify particular network changes during adolescence that explain why this developmental window is the peak onset time for pathological anxiety? To explore these questions, we use both behavioral tasks and magnetic resonance imaging (MRI). Imaging modalities include (resting and task) functional MRI (fMRI), diffusion-weighted imaging (DWI), quantitative MRI (e.g., magnetization transfer), and magnetic resonance elastography (MRE). To probe networks, we use graph theory tools, including a (publicly available) toolbox developed and maintained in the lab.​

Degrees

​Ph.D., University of Illinois at Urbana-Champaign

Courses Regularly Taught

​NSCI438: Clinical Neuroscience

Recent Publications

Matyi MA, Cioaba S, Banich MT, & Spielberg JM. (2021). Identifying brain regions supporting amygdalar functionality: Application of a novel graph theory technique. NeuroImage, 244, 118614. doi:10.1016/j.neuroimage.2021.118614   

Matyi MA, & Spielberg JM. (2021). Differential spatial patterns of structural connectivity of amygdala nuclei with orbitofrontal cortex. Human Brain Mapping, 42(5), 1391-1405. doi:10.1002/hbm.25300 See Tools/Data to download the associated atlases.

​Dr. Spielberg's Research Gate Profile​

Representative Publications

Spielberg JM, Beall EB, Hulvershorn LA, Altinay M, Karne H, & Anand A. (in press). Resting state brain network disturbances related to hypomania & depression in medication-free bipolar disorder. Neuropsychopharmacology. doi:10.1038/npp.2016.112

Spielberg JM, Miller GA, Heller W, & Banich MT. (2015). Flexible brain network reconfiguration supporting inhibitory control. Proceedings of the National Academy of Sciences, 112(32), 10020-5. doi:10.1073/pnas.1500048112

Spielberg JM, McGlinchey RE, Milberg WP, & Salat DH. (2015). Brain network disturbance related to posttraumatic stress & traumatic brain injury in veterans. Biological Psychiatry, 78(3), 210-6. doi:10.1016/j.biopsych.2015.02.013

Spielberg JM, Jarcho JM, Dahl RE, Pine DS, Ernst M, & Nelson EE. (2015). Anticipation of peer evaluation in anxious adolescents: divergence in neural activation & maturation. Social Cognitive & Affective Neuroscience, 10(8), 1084-91. doi:10.1093/scan/nsu165

Spielberg JM, Forbes EE, Ladouceur CD, Worthman CM, Olino TM, Ryan ND, & Dahl RE. (2015). Pubertal testosterone influences threat-related amygdala-orbitofrontal coupling. Social Cognitive & Affective Neuroscience, 10(3), 408-15. doi:10.1093/scan/nsu062

Spielberg JM, Miller GA, Warren SL, Engels AS, Sutton BP, & Heller W. (2014). Transdiagnostic dimensions of anxiety and depression moderate motivation-related brain networks during goal maintenance. Depression & Anxiety, 31(10), 805-13. doi:10.1002/da.22271​

Spielberg JM, Heller W, & Miller GA. (2013). Hierarchical brain networks active in approach and avoidance goal pursuit. Frontiers in Human Neuroscience, 7, 284. doi:10.3389/fnhum.2013.00284

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Psychological and Brain Sciences
Main Office: Wolf Hall 108
105 The Green
University of Delaware
Newark, DE 19716, USA
Phone: 302-831-2271