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I am an associate professor originally from Trinidad and Tobago. I did my undergraduate schooling at North Carolina Central University (HBCU), masters and PhD training at The Ohio State University, and postdoctoral study at the University of Michigan Medical School. My research interests concerns stress and learning and memory. Peripheral hormones and central ascending arousal systems contribute to emotional learning and memory. These systems are also sensitive to stress, and under certain circumstances, may contribute to emotional memory processes that contribute to psychiatric disorders (e.g. PTSD, substance abuse). My research interests concern exploring how stress-induced changes in peripheral hormonal, ascending arousal, and emotional circuit systems contribute to stress-induced effects that model specific symptoms in psychiatric disorders.
Brain and Behavior, Introduction to Neuroscience, Integrative Neuroscience I, and Integrative Neuroscience II
Dr. Knox's NCBI Link
Examining Mechanisms via which Traumatic Stress Leads to Post Traumatic Stress Disorder Using Animal Models: Advantages, Pitfalls, and Future Directions. (2022). Eds. Knox, D., Sabban, E., Morinobu, S. Frontiers Inc.
Shultz, B*., Farkash, A. •,, Collins, B. •,, Mohammadmirzaei, N.*, and Knox., D. (2022). Fear learning-induced changes in AMPAR and NMDAR expression in the fear circuit. Learning & Memory, 29(3): 83-92.
Knox, D., Stout-Oswald, S. A., Tan, M., George, S. A., and Liberzon, I. (2021). Maternal separation induces sex-specific differences in sensitivity to traumatic stress. Frontiers in Behavioral Neuroscience, 15: ecollection.
Mohammadmirzaei, N*., Biddle, M*., Hekmatayar, K., Cai, X., Kulkarni, P., and Knox, D. (2021). The Effect of Traumatic Stress on the Mu-Opioid Receptors and Connectivity Within Reward Circuits. Biological Psychiatry, 89(9): S197.
Knox, D. (2021). Issues with Using Animal Models to Examine Sex Differences in Developing PTSD. Biological Psychiatry, 89(9): S48-S49.
Ferland-Beckham, C., Chaby L.E., Daskalakis, N.P., Knox, D., Liberzon, I., Lim, M.M., McIntyre, C., Perrine, S.A., Risbrough, V.B., Sabban, E.L., Jeromin, A., and Haas, M. (2021). Systematic Review and Methodological Considerations for the Use of Single Prolonged Stress and Fear Extinction Retention in Rodents. Frontiers in Behavioral Neuroscience. 15: 652636.
Knox, D., Della Valle, R*. Mohammadmirzaei, N.*, Shultz, B.*, Biddle, M., Farkash, A. •, Chamness, M., and Moulton, E •. (2021). PI3K-Akt signaling in the basolateral amygdala facilitates traumatic stress enhancements in fear memory. International Journal Of Neuropsychopharmacology. 24(3):229-238. Citations - 2
Della Valle, R*. Mohammadmirzaei, N.*, and Knox, D. (2019). The role of sensory cortex, thalamic nuclei, and the periaqueductal gray in mediating changes in emotional memory in the single prolonged stress model of post traumatic stress disorder. Learning & Memory. 26 (10): 403-411. Citations – 3.
Kimmelmann-Shultz, B. *, Mohammadmirzaei, N. * Caplan, J., and Knox, D. (2019). Using near-infrared fluorescence and high resolution scanning to measure protein expression in the rodent brain. J. Vis. Exp. (147): e59685. Citations – 0
Moulton, E. •, Chamness, M. •, and Knox, D. (2018). Characterizing changes in glucocorticoid receptor internalization in the fear circuit in an animal model of post traumatic stress disorder. PLOS One 13(12): e0205144. Citations – 1.
Knox, D., George, S.A., Fitzpatrick, C.J., Rabinak, C., Maren, S., and Liberzon, I. (2012). Single prolonged stress disrupts retention of extinguished fear in rats. Learning & Memory, 19(2): 43 - 49.
George, S.A., Knox, D., Curtis, A., Aldridge, J.W., Valentino, R., and Liberzon, I. (2013). Altered noradrenergic activity in an animal model of PTSD. European Journal of Neuroscience 37, 901-909.
Knox, D. (2016). The role of basal forebrain cholinergic neurons in fear and extinction memory. Neurobiology of Learning and Memory 133: 39-52.
Knox, D. and Keller, S.M.* (2016). Cholinergic neuronal lesions in the medial septum and vertical limb of the Diagonal Bands of Broca induce contextual fear memory generalization and impair acquisition of fear extinction. Hippocampus 26(6): 718-726.
Knox, D. and Berntson, G. G. (2008). Cortical modulation by nucleus basalis magnocellularis corticopetal cholinergic neurons during anxiety-like states are reflected by decreases in delta. Brain Research 1227: 142 – 157.
Knox, D., Holly B., Norman, J. G., and Berntson G. G., (2008). Nucleus basalis magnocellularis and substantia innominata corticopetal cholinergic lesions attenuate freezing induced by predator odor. Behavioral Neuroscience 122(3): 601-610.
Knox, D., and Berntson, G. G., (2006). Effect of nucleus basalis magnocellularis cholinergic lesions on fear-like and anxiety-like behavior. Behavioral Neuroscience 120(2): 307-312.
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