The Zika
virus now active in numerous countries, and the severe birth defects
associated with it, makes it clear that infection in pregnant women can
have immediate and devastating effects on the developing baby.
“Zika is the example we all know about right now,” said
neuroscientist Jaclyn Schwarz, assistant professor in the University of
Delaware’s Department of Psychological and Brain Sciences.
“But any infection in a pregnant woman can affect the fetus, and we
also know that any immune response [the body’s defense against
infection] does affect your brain.”
Schwarz recently was awarded a five-year, $1.8 million grant from the
National Institutes of Health to support her research on infections
that occur either before or shortly after birth.
She’s looking into whether such an infection — from bacteria or any
other source that activates the body’s immune response to counteract it —
can be a risk factor for developmental disorders years later.
Among the possible disorders are learning disabilities and autism,
generally diagnosed in early childhood, and schizophrenia, often
diagnosed in late adolescence.
“We know from previous research that if Mom has influenza in the
second or third trimester, there’s an increased risk of mental health
problems later in the child’s life,” Schwarz said.
Of course, many people exposed to infection before birth or early in
life never experience developmental disorders. Schwarz thinks that an
early-life immune response is just the first step in a process that can
lead to such conditions.
“No one, single thing causes autism or schizophrenia, as far as we
know,” she said. “But we think that something happens with an infection
early in life that primes the brain to be vulnerable to other factors
that do lead to these kinds of disorders.”
Although the impact of early-life infections on brain development has
been studied by other researchers, Schwarz’s lab is interested in
filling in what she sees as some gaps in previous work.
One of those involves sex differences, which she said are often not
considered in research using animal models, as the investigators tend to
rely only on male rats, for example. But in humans, boys are diagnosed
much more often than girls with such disorders as autism and
schizophrenia, so some type of sex difference seems obvious, Schwarz
said.
“That suggests to me that boys are more vulnerable in utero to immune challenges,” she said.
“These sex differences have been ignored for a long time, so the
potential for discovery is huge. And the implications for health are
huge, too.”
Another gap in previous studies involves the tendency of researchers
to observe the effects of an infection on brain and behavior in newborns
and then in adults, Schwarz said. Instead, she plans to study the
effects at regular intervals throughout the lifespan.
She uses a rat model, challenging the immune system at a very young
age with an infection from which the rats recover in about 48 hours, she
said. She then explores the short- and long-term effects of that
infection on the brain, the immune system and behavior.
“The immune system responds to so many different things — alcohol,
drugs, virus, bacteria, toxins — that probably no one thing is the
answer to developmental disorders,” Schwarz said. “But I think the
immune system is a strong link to a number of things that happen later
in life.”
Ultimately, Schwarz hopes her project can help identify the point in
brain development at which things can start to go wrong and, by then
finding the markers for that process, future therapies can be developed
to intervene.
