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Jeffrey B. Rosen
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Associate Professor
Ph.D., Wayne State University
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jrosen@udel.edu |
Office:
227 Wolf Hall
(302) 831-4209
(302) 831-3645 -fax |
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Lab:
147 Wolf Hall
(302) 831-1462
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Preferred contact method - email |
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Research Interests
Neurobiology of Emotion
Research Summary:
My research interests in emotion are in understanding the physiological, neuroanatomical and molecular bases of fear and anxiety. To approach these problems, we study fear-related behaviors that have defined neuroanatomical circuits, such as fear-potentiated startle and fear-induced freezing or immobility in rats. Experiments are designed to study the pharmacology, biochemistry and molecular biology of fear within the neural circuits that mediate these fear-related behaviors. We use numerous techniques including brain stimulation and lesions, anatomical tracing, administration of drugs, and detection of proteins and messenger RNA using in situ hybridization, immunohistochemistry, and Northern and Western blotting.
Our current research has found specific, rapid changes in gene expression of transcription factors in fear circuits that are associated with learned fear in rodents. Other studies are finding that the neuroanatomical substrates of learned and innate fear may be different. In addition to delineating the neurobiology of fear, these studies should have important implications for our understanding of the neural basis of anxiety disorders.
Recent Publications
Rosen, J.B. (2007). Aversive Emotions: Molecular Basis of Unconditioned Fear. Larry Squire (Ed.), New Encyclopedia of Neuroscience. Elsevier, Amsterdam.
Rosen, J.B., West, E.A., Donley, M.P. (2006). Not all rat strains are equal: Differential unconditioned fear responses to the synthetic fox odor trimethylthiazoline in three outbred rat strains. Behavioral Neuroscience, 120, 290-297.
Rosen, J.B. and Donley, M.P. (2006). Animal studies of amygdala function in fear and uncertainty: Relevance to human research. Biological Psychology, 73, 49-60.
Thompson, B.L. and Rosen, J.B. (2006). Immediate-early gene expression in the central nucleus of the amygdala is not specific for anxiolytic or anxiogenic drugs. Neuropharmacology, 50, 57-68.
Schulkin, J., Morgan, M.A., and Rosen, J.B. (2005). A neuroendocrine mechanism for sustaining fear. Trends in Neurosciences, 28, 629-635.
Donley, M.P., Schulkin, J. and Rosen, J.B. (2005). Glucocorticoid receptor antagonism in the basolateral amygdala and ventral hippocampus interferes with long-term memory of contextual fear. Behavioural Brain Research, 164, 197-205.
Representative Publications
Rosen, J.B. (2004). The neurobiology of conditioned and unconditioned fear: A neurobehavioral system analysis of the amygdala. Behavioral and Cognitive Neuroscience Reviews, 3, 23-41.
Malkani, S., Wallace, K.J., Donley, M.P. and Rosen, J.B. (2004). An egr-1 (zif268) antisense oligodeoxynucleotide infused into the amygdala disrupts fear conditioning. Learning & Memory, 11, 617-624.
Thompson, B.L., Erickson, K., Schulkin, J. and Rosen, J.B. (2004). Corticosterone facilitates retention of contextually conditioned fear and increases CRH mRNA expression in the amygdala. Behavioral Brain Research, 149, 209-215.
Wallace, K.J. and Rosen, J.B. (2001). Neurotoxic lesions of the lateral nucleus of the amygdala decrease conditioned fear, but not unconditioned fear of a predator odor: comparison to electrolytic lesions. Journal of Neuroscience, 21, 3619-3627.
Wallace, K.J. and Rosen, J.B. (2000). Predator odor as an unconditioned fear stimulus in rats: Elicitation of freezing by trimethylthiazoline, a component of fox feces. Behavioral Neuroscience, 114, 912-922.
Malkani, S. and Rosen, J.B. (2000). Specific induction of early growth response gene 1 (EGR-1) in the lateral nucleus of the amygdala following contextual fear conditioning in rats. Neuroscience, 97, 693-702.
Rosen, J.B. and Schulkin, J. (1998). From normal fear to pathological anxiety. Psychological Review, 105, 325-350.
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